Michael

 

The Morgellons Research Foundation has said many times that cellulose has been detected in fibers that Morgellons patients found on the skin, or in their wounds. They are also quite interested in tests that showed Agrobacterium in wounds. (Agrobacterium is a bacterium that normally infects plants, but can infect humans with weakened immune systems, particularly with chronic skin trauma).

Agrobacterium is one of number of species that produce microbial cellulose. Of course this is of interest, since some fibers tested have been shown to contain cellulose. Could those fibers be microbial cellulose from Agrobacterium?

Recently some SEM photos were released that showed “Morgellons” fibers. I demonstrated that they looked just like cotton fibers, which are also made of cellulose. But could they actually be microbial cellulose? Here’s the photo of the Morgellons fibers:

new_pa3-1.jpg

Note the scale in the bottom left, 10µm, meaning the smooth fibers are about 10-15µm across.

Now look at some microbial cellulose:

microbialcellulosestructure.jpg

At first glance it looks plausible that it might be the same thing. But look at the scale in the bottom right (click on the photo to zoom in). It’s 2µm, meaning the microbial cellulose fibers are about 0.1µm across. 1/100th the size of the Morgellons fibers. Here’s what the microbial cellulose fibers would look like at the same scale as the Morgellons fibers.

ag_on_cotton.jpg

So, no, these “Morgellons” fibers do not in any way resemble microbial cellulose from Agrobactrium. In fact, they look exactly like cotton. They are made of the same thing as cotton. Cotton is in nearly all bandages and dressings, towels, clothes, furniture and household dust. Cotton fibers are everywhere. These “Morgellons” fibers are clearly cotton.

But one mystery remains – why are the “Morgellons” patients’ samples testing positive for Agrobacterium? That’s difficult to say for sure, but consider that the samples came from patients of Raphael Stricker, who treats some people that he thinks have Morgellons with very long term intravenous antibiotics – which are often administered via an indwelling venous catheter (meaning a catheter into a vein, that you leave in all the time). Consider this report:

http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=8448285&cmd=showdetailview

Agrobacterium infections in humans: experience at one hospital and review.
Agrobacteria are noted primarily for their phytopathogenicity [infecting plants] and when isolated from human clinical specimens are often considered contaminants or organisms of low pathogenicity [infecting humans]. We report six cases at one hospital over a 6 1/2-year period in which infection was accompanied by a compatible clinical syndrome and review 19 cases reported in the literature. Fourteen of the 25 combined cases involved central venous catheter-associated infections. Six cases involved peritonitis, five of which occurred in patients undergoing continuous ambulatory peritoneal dialysis. Additional infections included two non-catheter-associated bacteremias, one prosthetic valve endocarditis, and two urinary tract infections. Most infections were community acquired, and restriction enzyme analysis of Agrobacterium isolates from eight patients at one hospital revealed unique patterns in each case without evidence for clonal dissemination of these strains. Agrobacterium isolates may be resistant to multiple antibiotics, and optimal therapy has not yet been determined. Agrobacteria should be recognized as opportunistic pathogens in the immunocompromised host, particularly in those with indwelling plastic catheters.

So, several sick patients from Stricker’s patient community, who probably had indwelling plastic catheters, tested positive for Agrobacterium, and found cotton in their wounds.

 

There are some new photos on the MRF web site, including this one:

new_pa3-1.jpg

Which is captioned: “Ribbon-like fiber coated with minerals with a cylindrical fiber and faceted fiber adjacent“, with the implication being that this is some unusual fiber only found in Morgellons patients. But let me set this photo in a larger context:

combined-cotton2.jpg

I’ve taken the MRF photo and scaled it to the exact same scale as another (larger) photo. I’ve also taken two more photos and overlaid them to show detail of the “mineral” coated fiber. One image is just to the right of the middle, and the other is in the left. Note all I did here was rotate the images and moved them to similar regions. The images have been scaled to match (note the 100µm and the 10×10µm scales). Note the undamaged fibers are the exact same size, shape and texture in both photos, while the middle damaged fiber almost exactly matches the overlaid segments of damaged fiber.

All images are of cotton. The larger background image is of cotton thread, from here, the second inset image is of a water-damaged cotton fiber from here. Click on the above photo to zoom in and examine the cotton more closely. Note that they have the exact same “minerals” sprinkled over them. And not that the damaged fiber shows damage in the same way as the “Morgellons” fiber. Also the “faceted” fiber could quite possibly be a faceted fiber, like extruded polyester, but could equally well be a slightly twisted cotton fiber, such as those in the lower right.

Hence, the most likely explanation is that these are cotton, from any of: cotton bandages, cotton wool or cotton clothing.

Original images are linked below, click them to see full versions:

jaic40-02-002-ch2fg6.jpg jaic40-02-002-ch2fg4.jpguwbl-0412-w.jpg

Sources:

http://www.aber.ac.uk/bioimage/image/image.htm

http://aic.stanford.edu/jaic/articles/jaic40-02-002.html

 

The Morgellons story that is fed to the media contains several talking points that the reporters gladly repeat, ignoring the most obvious of explanations. Fibers are found on the skin. Fuzzballs are somehow deemed to look unusual. Fibers are found to glow under UV light. Patients’ physical symptoms are dismissed as psychological. Patients did not make their own lesions.

One that comes up over and over, is that Morgellons is found most in California, Texas and Florida, and there are hotspots of it in various cities. This is generally quite explainable by the fact that more people live in those states, and cities, so obviously there would be more cases there. But there is one claim that seems to actually give weight to the MRFs claim of an unusual distribution. From their web site:

Although California represents 12% of the US population, 24% of all families in the U.S. who have registered with the Morgellons Research Foundation reside in California

So that’s twice as many cases as you would expect by random chance! Clearly something is going on! Does this prove Morgellons?

Firstly, it simply shows that the MRF database does not represent a random sampling of the US population. You could interpret this in a number of ways, both pro and con. If Morgellons were an infectious disease, then you could argue that you would expect a more even spread, and the concentration in California perhaps indicates it’s something environmental, like ticks. (unfortunately, most ticks are in the Eastern US).

But we don’t really need to reach very far for explanations. Indeed, we should be remembering Occam here, and not introducing new entities into the mix. The reason for the high concentration of cases in California can be found on one page of the MRF’s web site, their list of television news stories about Morgellons.

http://morgellons.org/tele.htm

One thing that becomes clear is that there are simply a lot of television shows on Morgellons that showed in California. I broke it down into California and Texas

Station City State Shows Population (Metro) Exposure
KTVU San Francisco CA 3 7,236,391 21,709,173
KCBS Los Angeles CA 2 12,950,129 25,900,258
KGTV San Diego CA 1 2,941,454 2,941,454
CBS5 San Francisco CA 1 7,236,391 7,236,391
        TOTAL CA 57,787,276
KXAN Austin TX 1 1,513,565 1,513,565
KVUE Austin TX 1 1,513,565 1,513,565
KPRC Houston TX 1 5,539,949 5,539,949
WOAI San Antonio TX 1 1,942,217 1,942,217
KHOU Houston TX 1 5,539,949 5,539,949
KENS San Antonio TX 3 1,942,217 5,826,651
        TOTAL TX 21,875,896

Look how much bigger the cities are in California. Even though the number of shows is about the same, there’s nearly three times the audience exposure in CA as there is in TX. When you take the relative population of CA (36.5Million) and TX(23.5 MIllion), you come up with a figure of 1.7 times. That 1.7 times as many people (as a percentage of the state population) in California saw a local TV show on Morgellons as did in Texas (math: (57.7/36.5)/(21.8/23.5) = 1.7). Given that the Texas figures are also going to be above the national average, due to its extensive local TV coverage, then it’s hardly surprising that California has 2 times the national average of the incidence of people who heard about Morgellons and decided to visit the MRF web site, and eventually register.

So you see, the MRF’s database IS a random sampling of the US population. Just weighted by media coverage.

 

“patients’ symptoms are often dismissed as psychological by health care practitioners”
Morgellons Research Foundation web site

 

“Physical and neurological symptoms are often dismissed or ignored”
Oklahoma State University Center for Health Sciences Center for the Investigation of Morgellons Disease

The above statements are representative of something that is often repeated regarding Morgellons, in that the patients are somehow being ignored, or dismissed. Particularly that their symptoms are being dismissed as “psychological”.

This conjures up various scenarios, of various plausibility for each of the Morgellons symptoms:

Patient: Doctor, I’ve got this horrible itching sensation, it keeps me awake at night, it feels like bugs crawling under my skin.
Doctor: You’re just imagining it.

Patient: Doctor, I’ve got these nasty looking sores on my arms
Doctor: You’re just imagining them

Patient: Doctor, I feel tired all the time.
Doctor: You’re just imagining it.

Patient: Doctor, I found some fibers on my skin, some were in the sore I showed you.
Doctor: You’re just imagining it.

Patient: Doctor, I saw a cobalt blue fiber poking out of the scalp, I tried to pull it out, but it withdrew back into the scalp and reappeared a few moments later in another area
Doctor: Sounds unlikely.

Of these, only the last is something that is likely going to be “dismissed as psychological”. The “finding of fibers on the skin” is not going to be dismissed as psychological, since fibers are everywhere, and everyone has them on their skin.

The root symptoms for many people who identify as having Morgellons are itching and crawling sensations. This causes people to scratch and pick at their skin, hence producing sores. The itching causes sleep deprivation, which might lead to fatigue and confusion.

So, under what circumstances would a doctor dismiss itching as “purely psychological”? Suppose you went to the doctor, and told him: “Doctor, I’m itching really bad, feels like bugs crawling under my skin”. How quickly would the doctor say “you are just imagining it”?

Consider for a second all the causes of itching, if we go to http://www.wrongdiagnosis.com/symptoms/itching_skin/causes.htm, you’ll see there are 646 disease that have itching as a symptom. Not only that, but there are 1742 medications that cause itching skin. Given this vast array of possible causes, obviously a doctor is not going to dismiss every report of itching as being “purely psychological”.

But here our patent said “it feels like bugs crawling under my skin”. Would a doctor automatically dismiss this? No. This sensation is generally either an actual infestation of bugs, like scabies, or it’s “formication“, which is a well known symptom of many physical conditions including diabetes and menopause.

So what would the doctor dismiss as purely psychological? Well, suppose the patient had actually said “I think I’ve got bugs crawling under my skin”. The doctor would look at their skin, and if there were no scabies they would explain that this is formication, and then go on to look for possible causes. At this stage there is no dismissing.

Suppose that no scabies are found, formication is explained, and the patient still continues to say “I believe I have bugs under my skin”, then at this stage, the doctor might begin to suspect that the patient is delusional.

So what is the doctor actually dismissing? They are dismissing the delusion as purely psychological. The thing that is psychological is the fixed false belief that their crawling and biting sensations are caused by parasites under their skin. This does not mean that the crawling and biting sensations are psychological.

That’s important, so I’m going to repeat it.

Just because a patient holds a false belief regarding the cause their itching, biting and crawling sensations, this does not mean their itching biting and crawling sensations are “purely psychological”. The only thing that is in any sense “purely psychological” is their false belief about the cause of those sensations.

If I have headaches, but I attribute those headaches to FBI mind control rays, then this does not mean that my headaches are purely psychological. It just means I hold a delusional belief about the cause of those headaches.

So, yes, delusions are psychological. If a patient thinks that living fibers are burrowing into his eyeballs, then that’s probably psychological. But even here, doctors do not “dismiss”. A delusion can be quite a serious problem. It’s hardly something to brush aside. But at the same time, it’s very difficult to discuss with the patient. For the patient, if you question their delusion, you are questioning the whole basis of their illness. To these patients, it might feel like you are “dismissing their symptoms as psychological”, when in fact you are simply noting that they have one delusional belief regarding their real physical symptoms.

The MRF and the OSU-CHS-CIMD exist to raise public awareness of Morgellons and to raise funds. So it suits their purposes to claim that patients are having their physical symptoms dismissed. But it’s ultimately disingenuous, as doctors do NOT dismiss physical symptoms. They don’t even dismiss psychological symptoms. But some patients hold delusional beliefs regarding the causes of their physical symptoms. They then claim that, since the doctor tried to explain that this was a delusion (and perhaps treat it), then their physical symptoms were being dismissed as psychological.

In reality, the only symptoms that were being “dismissed” as psychological, were the psychological symptoms.

 

In their recent paper, Stricker and Savely said:

“[...] the apparent response to antibiotic therapy supports the concept that Morgellons disease may be triggered by an infectious process”

Morgellons is not a recognized disease, it’s a list of symptoms. Some people have self-diagnosed with some those symptoms, and some doctors (a very small number) think that this means that the list of symptoms is indicative of a distinct disease. The above statement is typical of the reasoning they use.

So if “Morgellons” is not a distinct disease caused by an infectious agent, then why would antibiotics help people who have some of this list of symptoms? Let’s look at the symptoms again, from the above paper:

# Skin lesions accompanied by intense itching
# Crawling sensations on and under the skin, often compared to insects moving, stinging or biting (cutaneous dysesthesia)
# Fibers, which can be white, blue, red or black, in and on the lesions
# Fatigue significant enough to interfere with daily activity
# Musculoskeletal pain
# Inability to concentrate and difficulty with short-term memory
# Behavioral changes

Fibers, we have dealt with before. Nobody has shown they are anything other than normal environmental contaminants (hair, lint, clothing fibers, paper fibers). After five years of looking at them, it seems fairly clear that this is all they are. No new evidence is presented, so let’s look at the other symptoms.

Musculoskeletal pain, intense itching and crawling sensations are obviously going to seriously interfere with your sleep (disrupted sleep is another commonly listed Morgellons symptom). Sleep deprivation leads to fatigue, difficultly concentrating, and behavioral changes. Sleep deprivation can cause other problems, even leading to diabetes.

So what we might have is people with intense itching and crawling sensations, and other pain, that keeps them awake at night, so they develop “brain fog”.

So where do antibiotics fit in?

Well, for one things, the cause of the itching/crawling might in fact be an infection such as staph or folliculitis, which is treated by antibiotics. But an often overlooked property of many antibiotics is that they are also anti-inflammatory. They can also, apparently, “Inhibit Staphylococcal Exotoxin-Induced Cytokines and Chemokines“, which is interesting since the MRF states that elevated cytokines is a common laboratory abnormality for Morgellons. If they hence judge reduced cytokines to be an indicator that antibiotics are addressing an infectious source of “Morgellons”, then they might be jumping to conclusions.

The point here is that it is entirely possible the antibiotics provide purely symptomatic relief to people who have some of the symptoms on the Morgellons list. Morgellons patients and Morgellons doctors almost invariably note that the relief ends when the antibiotic treatment stops. What if these extreme doses of antibiotics are not actually addressing some underlying infectious agent, but instead are simply suppressing the symptoms via their mild anti-inflammatory effects? If this is so, then those doctors provide their patients a grave disservice.

© 2012 Morgellons Watch Suffusion theme by Sayontan Sinha